Filiations et affiliations entre génétique et clinique : la production de la différence (notice n° 701522)
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| fixed length control field | 04546cam a2200361 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250121213434.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Giacobino, Ariane |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Filiations et affiliations entre génétique et clinique : la production de la différence |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2013.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 35 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Cet article aborde la problématique clinique de la filiation et de l’affiliation d’une part à partir de la détermination génétique et d’autre part à partir des processus de marquages environnementaux épigénétiques, en se centrant sur la question de la production de la variation interindividuelle et de sa transmission entre les générations. En effet, on peut voir la génétique comme nous réduisant à une entité codée, nous définissant comme issu de- et descendant de-, mais aussi, à la lumière des connaissances nouvelles sur les millions de variants de séquence ADN et leurs combinaisons, comme un imprédictible. Dans ce sens, les modulations chimiques du génome, par l’environnement, nous rapportent à être élément génétique instable, en constante évolution. De plus, ces modifications épigénétiques ont été démontrées transmissibles au travers de quelques générations, et font donc intervenir dans notre filiation, la transmission de ce que l’environnement nous fait devenir. Si à cela on ajoute la stochasticité, ou l’aléatoire de certains processus biologique, tous les éléments concordent pour nous penser comme fondamentalement, et génétiquement, imprévisibles. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Filiation and affiliation : a bridge producing difference, between genetics and clinicsThis paper presents the questions raised by filiation and affiliation, with, on one side, genetic determination, and, on the other side, environmental processes leading to epigenetic changes. Production of interindividual variations and their transgenerational transmission are here seen as central elements. Indeed, our genetic background can be seen as a defined DNA code, we received from- and we will transmit to-, but also, as a unique combination of millions of genomic sequence variations. Recently, epigenetic modifications have also permitted to understand our genome as an interface for the environment to act on gene expression regulation, by chemical modification of DNA. These epigenetic changes, not only follow our environmental exposures, but are also potentially transmissible through generations, meaning that we transmit the marks from our environment, and how our environment has modified our genome. On the top of that, stochasticity or random variations within biological processes, also bring elements in our becoming in favour of thinking ourselves as non predictable. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Este artículo aborda la problemática de la filiación y de la afiliación ; de un lado a partir de la determinación genética, y de otro a partir de los procesos de los marcadores medioambientales epigenéticos, centrándose en la cuestión central de la producción de la variación interindividual y de la transmisión entre las generaciones. Una cierta concepción de la genética puede reducirnos a una entidad codificada, definiéndonos como descendientes de. Pero los nuevos conocimientos sobre las millones de variaciones de secuencia de ADN y de sus combinaciones, nos permiten comprendernos como impredecibles. En este sentido las modulaciones genéticas del genoma por el medio ambiente producen seres genéticamente inestables, en evolución constante. Además se ha demostrado que estas modificaciones epigenéticas son transmisibles a través de algunas generaciones, haciendo intervenir en la filiación la transmisión de lo que el medio ambiente modifica en cada quien. Si a esto añadimos la estocasticidad, o lo que hay de aleatorio en ciertos procesos biológicos, todos los elementos concuerdan para pensarnos como fundamental y genéticamente imprevisibles. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | génome |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | environnement |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | clinique |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | altérité |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | filiation |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | identité |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | génétique |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | identity |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | clinics |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | otherness |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | genetics |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | filiation |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | genome |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | environment |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ansermet, François |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | L'Autre | Volume 14 | 1 | 2013-07-01 | p. 15-23 | 1626-5378 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-l-autre-2013-1-page-15?lang=fr&redirect-ssocas=7080">https://shs.cairn.info/revue-l-autre-2013-1-page-15?lang=fr&redirect-ssocas=7080</a> |
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