Toxines urémiques de moyen poids moléculaire : un véritable regain d’intérêt (notice n° 759733)
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| fixed length control field | 03862cam a2200361 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250123101938.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nlandu, Yannick |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Toxines urémiques de moyen poids moléculaire : un véritable regain d’intérêt |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2019.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 13 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | La mortalité cardiovasculaire des patients atteints d’une maladie rénale chronique reste un problème majeur. À côté des facteurs de risque traditionnels, les toxines urémiques, dont les molécules de poids moléculaire moyen, participent de façon non négligeable à ce surcroît de mortalité, en générant et en entretenant un état inflammatoire chronique dit de bas grade. Ces molécules sont l’objet d’un intérêt croissant depuis quelques années et une grande partie des toxines urémiques associées à cette surmortalité cardiovasculaire a été identifiée : le FGF23, les cytokines, la pentraxin-3 et récemment les chaînes légères. Plusieurs études épidémiologiques ont mis en évidence l’interaction entre toxines urémiques, inflammation et/ou stress oxydatif, et mortalité cardiovasculaire et globale. L’utilisation des thérapies antioxydantes et/ou des anticorps dirigés contre les toxines ou leur site d’action, n’ont pas jusqu’à ce jour apporté un réel bénéfice sur la morbi-mortalité. Des espoirs se sont tournés récemment vers l’utilisation de nouvelles membranes d’hémodialyse dite medium cut-off (MCO), qui ont l’avantage d’épurer les toxines urémiques de poids moléculaire moyen sans une perte significative d’albumine. Néanmoins, les effets bénéfiques de ces nouvelles membranes sur la morbi-mortalité chez les patients dialysés restent à démontrer. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Cardiovascular mortality in patients with chronic kidney disease remains a major problem. The uremic toxins among which the molecules of middle molecular weight are counted contribute significantly to this high mortality, alongside the traditional risk factors. They generate and maintain a chronic inflammatory state called low-level chronic inflammatory state. A growing interest in these molecules has been noted for some years and the uremic toxins associated with this cardiovascular mortality are currently identified: FGF23, cytokines, pentraxin-3 and recently light chains. The existence of an interaction between uremic toxins, inflammation and/or oxidative stress and cardiovascular mortality is well reported in the various epidemiological studies. While the use of anti-oxidative therapies and/or antibodies against uremic toxins or their site of action have not yet yielded a real benefit, hopes are turning to the use of new hemodialysis membranes medium cut-off (MCO), which have the advantage of purifying the uremic toxin middle molecules without a significant loss of albumin. However, additional works are needed to demonstrate the use of these membranes will lead to modulate the morbi-mortality in the dialysis patients. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Maladie rénale chronique |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Molécules de poids moléculaire moyen |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Dialyse |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Toxines urémiques |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Membranes d’hémodialyse |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Chronic kidney disease |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Middle molecules |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Dialysis membranes |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Uremic toxins |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Padden, Michael |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Seidowsky, Alexandre |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hamaz, Sarah |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Vilaine, Éve |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cheddani, Lynda |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Essig, Marie |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Massy, Ziad |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Néphrologie & Thérapeutique | Volume 15 | 2 | 2019-02-26 | p. 82-90 | 1769-7255 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-nephrologie-et-therapeutique-2019-2-page-82?lang=fr&redirect-ssocas=7080">https://shs.cairn.info/revue-nephrologie-et-therapeutique-2019-2-page-82?lang=fr&redirect-ssocas=7080</a> |
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