Effets de l’inhibition post-natale de RANKL sur l’éruption et la formation radiculaire des molaires de souris C57BL/6 (notice n° 767975)
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| control field | 20250123104638.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Gama, Andrea |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Effets de l’inhibition post-natale de RANKL sur l’éruption et la formation radiculaire des molaires de souris C57BL/6 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2019.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 5 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction : Des observations récentes effectuées dans le service d’ODF de la Pitié-Salpêtrière à Paris montrent une augmentation des altérations de l’éruption des molaires permanentes non-familiales. Nos travaux récents au laboratoire montrent l’implication des ostéoclastes (OC) dans les processus d’éruption et de rétention dentaires avec implication de la voie de signalisation RANKL/RANK/OPG. Ces faits nous ont amenés à émettre l’hypothèse d’une étiologie environnementale à l’origine de ces défauts d’éruption qui correspondrait à la perturbation des voies de signalisation cellulaires autocrines/paracrines telles que la voie RANKL/RANK/OPG. Matériels et méthodes : Des souris C57BL/6 ont subi des injections d’anticorps anti- RANKL à intervalles réguliers au cours des neuf premiers jours après la naissance. Une comparaison phénotypique avec les souris transgéniques RANK a permis la caractérisation fonctionnelle de la voie RANK/RANKL. Le complexe dento-alvéolaire a été analysé par micro-CT pour la densité osseuse, et la coloration au trichrome de Masson pour les examens histologiques. Résultats : L’invalidation transitoire de RANKL a conduit à un arrêt du développement radiculaire des molaires et l’inhibition de l’éruption dentaire contrairement au phénotype des souris surexprimant RANK. Le recrutement et l’activité des ostéoclastes ont été fortement altérés. Discussion : Ces recherches présentent un intérêt clinique tant direct concernant la compréhension des pathologies de l’éruption qu’indirect pour l’établissement des protocoles de traitements orthodontiques pour les cas particuliers. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Recent observations performed in the orthodontic department of La Pitié-Salpêtrière hospital in Paris reported an increase of non-familial eruption defects of permanent molars. Our recent data have evidenced the involvement of osteoclasts (OC) in both the eruption and the dental retention processes through the RANKL/RANK/OPG signaling pathway. These facts are at the origin of the hypothesis of the existence of an environmental etiology for those eruption defects that would correspond to the perturbation of cellular autocrine/paracrine signaling pathways as the RANKL/ RANK/OPG. Materials and methods: C57BL/6 mice were submitted to repeated injections with anti-RANKL neutralizing antibody during the nine days following birth. A phenotypic comparison with transgenic mice overexpressing RANK was performed for the functional characterization of the RANKL/RANK/OPG pathway. The dento-alveolar complex was analyzed using micro-CT for bone density and Masson’s trichrome staining for histological examination. Results: The RANKL transient invalidation of RANKL stopped the molar root development and tooth eruption contrary to transgenic mice overexpressing RANK. The recruitment and the OC activity were strongly impacted. Discussion: This research is of direct clinical interest in understanding the pathology of eruption as indirect in establishing orthodontic treatment protocols for particular cases. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Follicule dentaire |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | RANK |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | RANKL |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Défauts primaires d’éruption |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Primary failure of eruption |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | RANK |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | RANKL |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Dental follicle |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Perea, Linamary |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yepes, Catalina |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Betancur, Jhon J. |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Vargas, Jorge |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amiaud, Jerôme |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Babajko, Sylvie |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lezot, Frédéric |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Castaneda, Beatriz |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | L'Orthodontie Française | 90 | 1 | 2019-01-01 | p. 55-63 | 1966-5202 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-l-orthodontie-francaise-2019-1-page-55?lang=fr&redirect-ssocas=7080">https://shs.cairn.info/revue-l-orthodontie-francaise-2019-1-page-55?lang=fr&redirect-ssocas=7080</a> |
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