High Antiurolithiatic Capacities of Isolated Fractions of the Hydromethanolic Extract from Pituranthos scoparius Roots (notice n° 782631)
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| fixed length control field | 05286cam a2200301 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250123112808.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Benalia, H. |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | High Antiurolithiatic Capacities of Isolated Fractions of the Hydromethanolic Extract from Pituranthos scoparius Roots |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2020.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 76 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Natural products, such as plant extracts, open a new horizon for the discovery of new antiurolithiatic agents. In Algeria Pituranthos scoparius commonly known as “guezzah”, one of the most important plants medicinal Saharan is used for the treatment and prevention of urinary lithiasis. The present study deals with the in vitro evaluation of the inhibitory effect on the formation of calcium oxalate kidney stones of isolated fractions from Pituranthos scoparius roots hydromethanolic extract. First, the study led to the isolation of four fractions (F1 = 107 mg, F2 = 19 mg, F3 = 7 mg, F4 = 18 mg) by combining two chromatographic techniques: open column chromatography and preparative thin layer chromatography (TLC). The in vitro antiurolithiatic activity of different isolated fractions has been carried out by two different models. In the turbidimetric assay, we have determined spectrophotometrically the effect of the isolated fractions (1g/l) on the oxalocalcic crystallization, induced by the addition of oxalate in urines from four subjects, whereas the gravimetric assay is used to measure the variation of uric acid and calcium urate renal calculi weight, after putting them in contact with 3 ml of the isolated fractions (1 g/l) during 30 days. In the two assays, the antiurolithiatic activity was compared with that of six antiurolithogenesis inhibitory standards: sodium citrate, succinimide pharbiol, foncitril, alcaphor, allopurinol, and phosphoneuros. The achieved results measured by the two tests show clearly that the fraction 1 (F1) has provided very important antiurolithiatic power (> 50% of inhibition) compared to the standard inhibitors. The in vitro obtained experimental results in this study show that the Pituranthos scoparius roots are a biologically active natural source for the treatment of oxalocalcic lithiasis. Therefore, further experiments will be required to identify the molecules involved in the antiurolithiatic effect and to study their in vivo effects, which can be used therapeutically. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Les produits naturels, tels que les extraits de plantes, ouvrent un nouvel horizon à la découverte de nouveaux agents antilithiasiques urinaires. En Algérie, Pituranthos scoparius, communément appelé guezzah, est l'une des plus importantes plantes médicinales sahariennes utilisées pour le traitement et la prévention de la lithiase urinaire. La présente étude porte sur l'évaluation in vitro de l'effet inhibiteur sur la formation de calculs rénaux d'oxalate de calcium à partir de fractions isolées de l'extrait hydrométhanolique de racines de Pituranthos scoparius. Premièrement, l'étude a permis d'isoler quatre fractions (F1 = 107 mg, F2 = 19 mg, F3 = 7 mg, F4 = 18 mg) en combinant deux techniques chromatographiques : la chromatographie sur colonne ouverte et la chromatographie préparative en couche mince. L'activité antilithiasique urinaire in vitro de différentes fractions isolées a été déterminée par deux modèles différents. Dans l'analyse turbidimétrique, nous avons déterminé par spectrophotométrie l'effet des fractions isolées (1 g/l) sur la cristallisation oxalocalcique, induite par l'addition d'oxalate dans les urines de quatre sujets. Alors que l'analyse gravimétrique est fondée sur la mesure de la variation de poids de l'acide urique et de l'urate de calcium du calcul rénal, après les avoir mis en contact avec 3 ml des fractions isolées (1 g/l) pendant 30 jours. Dans les deux essais, l'activité antilithiasique urinaire a été comparée à celle de six étalons inhibiteurs de l'urolithogenèse : citrate de sodium, succinimide pharbiol, foncitril, alcaphore, allopurinol et phosphoneuros. Les résultats obtenus mesurés par les deux tests montrent clairement que la fraction 1 (F1) a fourni un pouvoir antilithiasique très important (> 50 % d'inhibiteur) par rapport aux inhibiteurs classiques. Les résultats expérimentaux obtenus in vitro dans cette étude montrent que les racines de Pituranthos scoparius sont une source naturelle biologiquement active pour le traitement de la lithiase oxalocalcique. Par conséquent, d'autres expériences seront nécessaires pour identifier les molécules impliquées dans l'effet antilithiasique et d'étudier leurs effets in vivo, utilisables ensuite en thérapeutique. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Calculs rénaux |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Pituranthos scoparius |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Activité antilithiasique urinaire |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Isolement |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Antiurolithiatic activity |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Isolation |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Renal calculi |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Pituranthos scoparius |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahfoudi, R. |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Djeridane, A. |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Moyse, François |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Phytothérapie | 18 | 6 | 2020-12-01 | p. 386-398 | 1624-8597 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-phytotherapie-2020-6-page-386?lang=en&redirect-ssocas=7080">https://shs.cairn.info/revue-phytotherapie-2020-6-page-386?lang=en&redirect-ssocas=7080</a> |
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