Study of Antioxidant, Anti-inflammatory, Antinociceptive Activities and Toxicity of Stigmata of Zea mays Extracts (notice n° 782806)
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| fixed length control field | 05340cam a2200421 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250123112836.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ammor, K. |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Study of Antioxidant, Anti-inflammatory, Antinociceptive Activities and Toxicity of Stigmata of Zea mays Extracts |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2021.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 28 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This study aims to investigate phytochemical screening, total polyphenol and flavonoids content, antioxidant activities and to examine toxicity, anti-inflammatory and antinociceptive effects of different extracts of stigmata of Zea mays from Morocco. The flavonoids and total phenols content were performed for both extracts. The aqueous and hydro-ethanolic extracts were screened for their possible antioxidant activities by three test systems, namely DPPH free radical-scavenging, reducing power and molybdenum system. Oral and Sub-acute toxicity of the hydro-ethanolic extract was evaluated in vivo. Anti-inflammatory activity of the hydro-ethanolic extract was evaluated by Carrageenan-induced rat paw edema method. The antinociceptive effect was tested by using the formalin test. Phytochemical screening of the extracts revealed a presence of flavonoids, leucoanthocyans, heterosid sterodic, coumarins, alkaloids, cardiac glycosides, anthocyanins and tannins. The flavonoids and total phenols content show higher content of flavonoids and total phenols in the hydro-ethanolic extract. It showed better antioxidant activity than the aqueous extract in the three methods used. Furthermore, the hydro-ethanolic extract with a concentration of 250 and 500 mg/kg body weight inhibited the inflammation induced by carrageenan in rats at 66.67% and 86.67% compared to 60.8% for indomethacin at 10 mg/kg after 5 h of inflammation induction. However, at dose of 500 mg/kg extract showed a pro-inflammatory effect. In the formalin test, the tolerance time of the rats was significantly higher compared to the control group. These initial results tend to support the traditional use in the treatment of cystitis, oliguria, nephritis, renal lithiasis edema, albuminuria, heart disease, slimming cures of stigmata of Zea mays in Morocco. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Cette étude a pour objectif d'étudier le criblage phytochimique, la teneur totale en polyphénols et en flavonoïdes, les activités antioxydantes et d'examiner la toxicité, les effets anti-inflammatoires et antinociceptifs de différents extraits de stigmates de Zea mays du Maroc. La teneur en flavonoïdes et en phénols totaux a été réalisée pour les deux extraits. Les extraits aqueux et hydroéthanoliques ont été criblés en fonction de leurs activités antioxydantes potentielles par trois systèmes de test, à savoir le piégeage des radicaux libres par le DPPH, le pouvoir réducteur et le système au molybdène. La toxicité orale et subaiguë de l'extrait hydroéthanolique a été évaluée in vivo. L'activité anti-inflammatoire de l'extrait hydroéthanolique a été évaluée par la méthode de l'œdème de la patte de rat induite par le carraghénine. L'effet antinociceptif a été testé en utilisant le test du formol. Le dépistage phytochimique des extraits a révélé la présence de flavonoïdes, de leucoanthocyanes, d'hétérosides stérodiques, de coumarines, d'alcaloïdes, de glycosides cardiaques, d'anthocyanines et de tanins. La teneur en flavonoïdes et en phénols totaux montre une teneur plus élevée en flavonoïdes et en phénols totaux dans l'extrait hydroéthanolique. Il a été montré que l'extrait aqueux dans les trois méthodes utilisées a une meilleure activité antioxydante. De plus, l'extrait hydroéthanolique à une concentration de 250 et 500 mg/kg de poids corporel inhibait l'inflammation induite par la carraghénine chez le rat à 66,67 et 86,67 % contre 60,8 % pour l'indométacine à 10 mg/kg après cinq heures d'induction de l'inflammation. Cependant à la dose de 500 mg/kg, l'extrait a montré un effet pro-inflammatoire. Dans le test au formol, le temps de tolérance des rats était significativement supérieur à celui du groupe témoin. Ces premiers résultats tendent à soutenir l'utilisation traditionnelle dans le traitement de la cystite, de l'oligurie, de la néphrite, de l'œdème de la lithiase rénale, de l'albuminurie, des maladies cardiaques, du traitement amincissant des stigmates de Zea mays au Maroc. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Activité anti-inflammatoire |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Activité antioxydante |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Stigmate de |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Zea mays |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Teneur en phénols totaux |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Toxicité |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Activité antinociceptive |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Teneur en flavonoïdes |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Antioxidant activity |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Antinociceptive activity |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Flavonoids content |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Toxicity |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Zea mays |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Anti-inflammatory activity |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Total phenol content |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Stigmata of |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amarti, F. Ez-zahra |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lagzizir, R. |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahjoubi, F. |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bousta, D. |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chaqroune, A. |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Phytothérapie | 19 | 4 | 2021-08-01 | p. 216-225 | 1624-8597 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-phytotherapie-2021-4-page-216?lang=en&redirect-ssocas=7080">https://shs.cairn.info/revue-phytotherapie-2021-4-page-216?lang=en&redirect-ssocas=7080</a> |
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