Dosage sanguin du phosphatidyléthanol (notice n° 83697)
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|---|---|
| fixed length control field | 03429cam a2200349 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250112000423.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hakim, Florian |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Dosage sanguin du phosphatidyléthanol |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2019.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 90 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | RésuméCet article se propose de situer le dosage sanguin du phosphatidyléthanol (PEth) dans le panorama du dépistage d’une consommation d’éthanol provoquant des troubles liés à l’usage d’alcool (TUA), et de présenter les méthodes d’analyse disponibles, les données d’interprétation, quelques applications pratiques et les perspectives d’utilisation de ce biomarqueur. Le PEth est un métabolite mineur de l’éthanol. Parmi près de 50 homologues du PEth existants, le PEth 16:0/18:1 est le plus abondant. L’intérêt que présente le PEth par rapport aux autres biomarqueurs est l’élargissement de la fenêtre de détection d’une consommation d’éthanol. En effet, il présente une demi-vie d’élimination sanguine d’environ 5 jours, ce qui permet une estimation des consommations d’alcool sur 21 à 28 jours. Ainsi, ses principales applications en routine se situent dans le dépistage des TUA et le suivi de sevrage (en association systématique avec le dosage urinaire d’éthylglucuronide) en addictologie et en pré- et post-transplantation hépatique. Des données demeurent cependant nécessaires pour parfaire l’interprétation des concentrations sanguines mesurées et parvenir à un consensus concernant les valeurs-seuils d’interprétation. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This article aims to place the phosphatidylethanol (PEth) blood test in the detection area of ethanol consumption causing alcohol-related disorders, to present the current methods of analysis, data on interpretation, some practical applications and the prospects of use of this biomarker. PEth is a minor metabolite of ethanol. Among nearly 50 PEth counterparts, PEth 16:0/18:1 is the most abundant. The interest that PEth brings compared to other biomarkers is the extended window of detection of ethanol consumptions. Indeed, it has a blood elimination half-life of approximately 5 days, which offers estimated alcohol consumption for a 21 to 28 days period. Thus, the detection of alcohol use disorders and withdrawal monitoring (systematically combined with urinary ethylglucuronide) in addictology and in liver pre- and post-transplantation are today its main routine applications. Nevertheless, additional data are still necessary to improve the interpretation of measured concentrations and to reach a consensus on interpretation cut-offs of blood PEth concentrations. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | phosphatidyléthanol |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | alcoolodépendance |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | applications cliniques |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | dried blood spot |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | spectrométrie de masse |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | (DBS) |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | dried blood spot (DBS) |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | alcohol dependence |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | phosphatidylethanol |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | clinical applications |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | mass spectrometry |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wiart, Jean-François |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ménard, Olivier |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Allorge, Delphine |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gaulier, Jean-Michel |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Annales de Biologie Clinique | 77 | 6 | 2019-12-01 | p. 638-644 | 0003-3898 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-annales-de-biologie-clinique-2019-6-page-638?lang=fr">https://shs.cairn.info/revue-annales-de-biologie-clinique-2019-6-page-638?lang=fr</a> |
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