Architecture et biogenèse des organelles de réplication des virus à ARN de polarité positive (notice n° 977505)
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| fixed length control field | 03085cam a2200301 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250125123726.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Bakhache, William |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Architecture et biogenèse des organelles de réplication des virus à ARN de polarité positive |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2019.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 19 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | La réplication des agents pathogènes viraux repose sur leur capacité à manipuler leur hôte à des fins provirales. De nombreuses étapes du cycle infectieux dépendent de l’usurpation des membranes cellulaires. Pour les virus possédant un génome composé d’un ARN de polarité positive (ARN(+)) et se répliquant dans le cytoplasme de leur hôte, la réorganisation et le détournement des membranes permettent en particulier la formation d’organelles membranaires hébergeant la réplication virale. La formation de ces compartiments constituant de réelles usines à virus donne lieu à des modifications morphologiques de l’hôte très variables selon le pathogène considéré. Les mécanismes moléculaires mis en jeu dans de tels remaniements restent le plus souvent incompris. Ils font cependant l’objet d’un intérêt intense puisque la formation de ces organelles de réplication, indispensables à la multiplication virale, représente une cible thérapeutique potentielle. Cette revue fait un état des lieux des connaissances relatives à l’architecture et aux interactions virus-hôte participant à la biogenèse des organelles de réplication des virus à ARN(+). |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The replication of viral pathogens relies on their ability to manipulate their host. Several steps of the infectious cycle require the hijacking of cellular membranes. Positive stranded RNA viruses replicating in the cytoplasm of their host reorganize cellular membranes. This leads to the formation of organelles, which host viral replication. The formation of such compartments, which are genuine viral factories, induces morphological modifications of the host cell, which vary depending on the pathogen. However, the molecular mechanisms underlying such a remodeling remain unclear. These mechanisms are subject to intense research since their formation is indispensable to viral multiplication and therefore represent an attractive therapeutic target. In this review, we provide a bird's eye view on the current knowledge of the architecture and virus-host interactions involved in the biogenesis of positive stranded RNA virus replication organelles. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | interactions hôte-virus |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | membranes |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | virus à ARN |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | organelles de réplication |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | virus-host interactions |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | membranes |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | replication organelles |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | RNA virus |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Couderc, Elodie |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Neyret, Aymeric |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Briant, Laurence |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Virologie | 23 | 3 | 2019-05-01 | p. 160-175 | 1267-8694 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-virologie-2019-3-page-160?lang=fr&redirect-ssocas=7080">https://shs.cairn.info/revue-virologie-2019-3-page-160?lang=fr&redirect-ssocas=7080</a> |
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