Capside du VIH et infection productive : comment arriver à bon pore ? (notice n° 977540)
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| fixed length control field | 03302cam a2200325 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250125123731.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Fernandez, Juliette |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Capside du VIH et infection productive : comment arriver à bon pore ? |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2020.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 53 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Résumé Le virus de l’immunodéficience humaine de type 1, agent causal du sida, a la particularité de pouvoir infecter des cellules qui ne se divisent pas ou peu, en bénéficiant d’un import nucléaire actif par le pore nucléaire afin de s’intégrer dans le génome de la cellule hôte. Bien qu’il soit désormais admis que le génome viral reste protégé par la capside virale après son entrée dans la cellule, les mécanismes permettant une décapsidation maîtrisée, essentielle à l’infection productive, restent peu compris. De nombreuses études montrent désormais que l’intégrité de la capside virale est essentielle au transport jusqu’au noyau, à l’efficacité de la transcription inverse et à l’import nucléaire, et pour limiter la reconnaissance du virus par les senseurs de l’immunité innée. Cette revue vise à faire le point sur l’état des connaissances actuelles sur les étapes précoces de l’infection par le VIH, depuis l’entrée dans la cellule jusqu’à l’intégration. En particulier les partenaires cellulaires de la capside virale qui favorisent ou inhibent l’infection, ainsi que des différentes techniques utilisées et/ou développées pour leur étude et l’identification de potentielles cibles thérapeutiques. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The Human Immunodeficiency Virus Type-1, the causative agent of AIDS, reaches its site of replication by trafficking through the cytoplasm towards the nucleus, benefiting from an active nuclear import through the nuclear pore in order to integrate in the genome of the host cell. Although it is generally accepted that the viral genome remains within the viral capsid for some time after cell entry, the mechanisms responsible for controlled uncoating, which is essential for productive infection, remain poorly understood. Numerous studies now show that the integrity of the viral capsid is essential for transport towards the nucleus, for reverse transcription and nuclear import, and to prevent sensing by innate immune receptors. This review aims to report recent developments in our understanding of the early stages of HIV infection, from entry into the cell to integration, highlighting the cellular partners of the HIV-1 capsid that promote or antagonize infection, as well as the different techniques that are developed for fundamental research and the identification of potential therapeutic targets. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | interactions hôte-virus |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | capside |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | restriction |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | pore nucléaire |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | réplication |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | VIH-1 |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | capsid |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | virus-host interaction |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | HIV-1 |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | nuclear pore |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | replication |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | restriction |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Arhel, Nathalie Jane |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Virologie | 24 | 2 | 2020-03-01 | p. 88-98 | 1267-8694 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-virologie-2020-2-page-88?lang=fr&redirect-ssocas=7080">https://shs.cairn.info/revue-virologie-2020-2-page-88?lang=fr&redirect-ssocas=7080</a> |
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