La 2′-O-méthylation : un grain de sable dans les rouages de la transcriptase inverse du VIH-1 (notice n° 978648)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02897cam a2200313 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250125124023.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Decombe, Alice |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | La 2′-O-méthylation : un grain de sable dans les rouages de la transcriptase inverse du VIH-1 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2024.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 26 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | HIV-1 polymerase, commonly known as HIV reverse transcriptase (RT), catalyzes the critical reaction of reverse transcription by synthesizing a double-stranded DNA copy of the viral genomic RNA. During the replication cycle, this synthesized DNA is integrated into the host genome. This entire process is essential for viral replication and is targeted by several antiviral drugs. Numerous studies in biochemistry and structural biology have led to a good understanding of HIV-1 RT functions. However, the discovery of epitranscriptomic marks, such as 2′-O-methylations, on the HIV-1 RNA genome raise the questions about RT’s ability to copy RNAs decorated with these biochemical modifications. This review focuses on the importance of RT in the viral cycle, its structure and function and the impact of 2′-O-methylations on its activity and replication regulation, particularly in quiescent cells. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Le VIH-1 possède une polymérase capable de réaliser la transcription inverse, processus de synthèse d’une copie ADN double brin à partir de l’ARN génomique. Au cours du cycle de réplication, l’ADN synthétisé est intégré dans le génome de la cellule infectée. La transcription inverse est donc essentielle à la réplication, et est la cible de thérapies antivirales. Des travaux en biochimie et en biologie structurale ont permis de mieux comprendre le fonctionnement de la polymérase du VIH-1, aussi appelée transcriptase inverse (RT). Cependant, la découverte de marques épitranscriptomiques telles que les 2′-O-méthylations sur le génome ARN du VIH-1, soulève la question de la capacité de la RT à recopier les ARN décorés par ces modifications biochimiques. Cette revue examine l’importance de la RT dans le cycle viral, sa structure et sa fonction polymérase, ainsi que l’impact des 2′-O-méthylations sur son activité et la régulation de la réplication qui s’exerce particulièrement dans des cellules quiescentes. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | ARN |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | polymérase |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | transcriptase inverse |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | 2′-O-méthylation |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | épitranscriptomique |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | 2′-O-methylation |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | epitranscriptomics |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | RNA |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | reverse transcriptase |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | polymerase |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Peersen, Olve |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Decroly, Étienne |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Virologie | 28 | 4 | 2024-07-01 | p. 277-293 | 1267-8694 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-virologie-2024-4-page-277?lang=fr&redirect-ssocas=7080">https://shs.cairn.info/revue-virologie-2024-4-page-277?lang=fr&redirect-ssocas=7080</a> |
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