Implications de l’alpha-2-macroglobuline dans l’hémostase et la thrombose (notice n° 996814)
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| fixed length control field | 03769cam a2200301 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250125132845.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Lagrange, Jeremy |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Implications de l’alpha-2-macroglobuline dans l’hémostase et la thrombose |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2023.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 30 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | RésuméLes antiprotéinases, telles que l’alpha-2-macroglobuline (A2M), ont différents rôles dans l’hémostase. L’A2M est une glycoprotéine homo-tétramérique de haut poids moléculaire hautement conservée dans l’évolution. L’inhibition des protéinases par l’A2M est permise par sa structure en formant une cage et en piégeant les protéinases sans inhiber directement leur activité enzymatique. La clairance des protéinases piégées est possible via la liaison de l’A2M au récepteur LRP1 (low density lipoprotein receptor-related protein 1). La synthèse d’A2M est contrôlée par des cytokines pro-inflammatoires, elle augmente dans plusieurs maladies inflammatoires chroniques ou aiguës et peut également varier avec l’âge. L’A2M piège de nombreuses protéinases impliquées dans la coagulation et la fibrinolyse, ce qui se traduit par une augmentation ou une inhibition de l’hémostase. L’A2M a la capacité d’inhiber la thrombine, le facteur Xa, la protéine C activée, la plasmine, l’activateur tissulaire du plasminogène et l’urokinase. L’A2M n’est généralement pas prise en compte dans le tableau de la régulation de l’hémostase. Les concentrations plasmatiques d’A2M sont modifiées dans les maladies inflammatoires. Elle a également la capacité d’inhiber des cytokines connues pour moduler l’hémostase. Cette revue a pour but de récapituler les fonctions connues de l’A2M en se concentrant sur ses fonctions dans l’hémostase et la thrombose. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Alpha-2-macroglobulin implications in hemostasis and thrombosisAlpha-2-macroglobulin (A2M) is an antiproteinase that plays different roles in hemostasis. A2M is a homo-tetrameric glycoprotein of high molecular weight highly conserved throughout evolution. Proteinase inhibitor activity of A2M is possible via a unique cage structure able to trap proteinase without having any direct inhibition regarding enzymatic activity. Clearance of trapped proteinase is achieved through A2M binding to the low-density lipoprotein receptor-related protein 1: LRP1. A2M synthesis is controlled by pro-inflammatory cytokines and increases in several chronic or acute inflammatory diseases and also varies with age. A2M can trap several proteinases involved in both coagulation and fibrinolysis, thus acting as a trigger and inhibitor of hemostasis. A2M is able to inhibit thrombin, factor Xa, activated protein C, plasmin, tissue-plasminogen activator and urokinase. A2M is usually poorly envisioned in hemostasis balance regulation. A2M plasma concentration are differently regulated during inflammatory-related diseases. It can also neutralize cytokines that are known to modify hemostasis as well. In this review, we propose to summarize known functions of A2M focusing on the roles of this antiproteinase in hemostasis and thrombosis. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | thrombose |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Alpha-2-macroglobuline |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | antiprotéinase |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | thrombine. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | thrombosis |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | alpha-2-macroglobulin |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | antiproteinase |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | thrombin |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Knopp, Tanja |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Schellenberg, Célia |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lecompte, Thomas |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Sang Thrombose Vaisseaux | Volume 35 | 1 | 2023-01-01 | p. 9-16 | 0999-7385 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-sang-thrombose-vaisseaux-2023-1-page-9?lang=fr&redirect-ssocas=7080">https://shs.cairn.info/revue-sang-thrombose-vaisseaux-2023-1-page-9?lang=fr&redirect-ssocas=7080</a> |
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