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Over the last decades, it has been demonstrated that opioid use disorder (OUD) results from the combined effects of many factors, including those of a psychosocial and neurobiological nature. This plurality is embodied in a comprehensive theoretical framework: the biopsychosocial model of addiction. While the impact of each factor on the severity of OUD has been well identified, their combined effect is unknown. In this context, the BEBOP project is based on a collaboration between psychiatrists, sociologists, and neuroepigeneticists. The primary objective is to characterize the severity of the psychosocial factors of OUD in a cohort of patients, with the aim of covering the full spectrum of the disorder’s severity. The secondary objectives are, first, to establish a correlation between the level of psychosocial severity and epigenetic biomarkers in order to understand the determinants of OUD severity, and, second, to determine whether epigenetic biomarkers can be predictive of OUD outcomes. Ultimately, the results of the BEBOP project will make it possible to tailor OUD treatment based on its severity.