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Dino del Garbo, an Italian physician active in the first decades of the fourteenth century, is well known for his commentary on Guido Cavalcanti’s poem Donna me prega. The present study offers a publication of a quodlibetical question on the imagination’s ability to alter the body, disputed in Bologna or Siena in the 1320s. We examine the medical and philosophical context in which this question occurs, by showing in particular how the debate gradually focused on the opposition between the Avicennian and Aristotelian models of the soul/body relationship. The analysis of this debate allows us to shed new light on Dino del Garbo’s commentary on Donna me prega and also, incidentally, on the poem itself.