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Based on the plastic/psychic representation of a family configuration, a pictorial representation of troubles in the filiation (a drawing made by the son of a patient and brought in by her), we aimed to gain (another) understanding of the transmission of anguish from one generation to the other, starting from the pain-matter that the patient brings home to her son from the sessions. This matter builds up painfully through analysis. In this clinical example, how is the anguish transmitted from the mother to the daughter (who has become a mother) and then to the son, under the gaze of the men-fathers (who are outside this matrice and accomplices of this suffering)? We call this intertwining of anguish a weaving process, meaning that the threads intertwine from one generation to the other and produce this more or less organized matter that is the “symptom-fabric.” I argue that anguish is a fabric whose threads have been woven together well in the past, and which comes undone in the sessions through the “talking cure” that is analysis.