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The goal of this article consists in constructing a path that links different forms of visual representation of the notion of social semiosis in the work of Eliseo Verón. The semiosis of the concept itself reveals the trajectory that goes from an initial moment in which the condition of materiality of the semiosis is emphasized to one in which we see the manifestation of the impossibility of having an accurate methodology to work on the gap between the phases of semiosis—the production and recognition instances. The proposal thus consists in approaches for constructing hypotheses about the possible effects of a process of significance.