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The development of a sensation of discomfort can allow for the identification of a physical and psychic invasion by disease, various identifying movements, and, especially, the emergence of anxiety. These three elements primarily concern cancer patients and they do not always leave their personal and health care environment untouched. This assertion is put to the test through the presentation of two clinical situations: the first refers to a hospitalized patient who has developed, among other things, a form of paralysis around it. The second patient related the experience of psychoanalytical work that she underwent, this having been quickly and definitively interrupted by the rapid evolution of a cancer patient over the course of psychotherapy. As a result, the catastrophic event of the disease is recounted mainly from the perspective of its impact on the psychotherapist.