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One generally considers that, beginning in the late 1960s, a “less (intellectually) rigorous” and even utterly hermetic W.R. Bion emerges, suddenly undermining the scientific approach that had guided his hypotheses up until then. By evoking the Kantian interdiction of access to the thing-in-itself, the present article attempts to show that instead of an ideological split or a theoretical recession, Bion’s introduction of his so-called “mystical” approach brings us closer to the duly thought-out conclusions of his epistemological research. Seemingly a dizzying turnaround, the current reading maintains that the common thread running through Bion’s works is that of the question of knowledge in general, and following in Freud’s footsteps, the question of knowledge of the unconscious in particular. Asserting the possibility of psychoanalysis also implies showing the way, both in theory and in practice, in which unconscious material – by definition inaccessible – acquires its interpretability through the analytical relationship.