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Several clinical manifestations of COVID-19 are possible, with digestive symptoms described in the literature. Sars-Cov-2 binds to ACE2 receptors in the body, and its expression is slightly higher in the pancreas than in the lungs. This expression plays an important role in clinical manifestations and severity. The involvement of the pancreas in COVID-19 can range from simple inflammation to severe pancreatitis. A 55-year-old woman was admitted to hospital with a confirmed case of severe Covid-19 with a pulse oxygen saturation of 89% on room air. She presented with severe transfixing abdominal pain in the epigastrium on about day 11 of symptom progression. Lipase levels were six times higher than normal. Abdominopelvic CT scan showed extensive fatty infiltration of the pancreas with loss of lobulation in the corporocaudal segment. The patient presented with three of the major criteria for the diagnosis of Atlanta acute pancreatitis. A diagnosis of Baltazar C acute pancreatitis was made, which progressed favorably with digestive rest and analgesics. All the usual causes of acute pancreatitis were ruled out in our patient. It is important to consider that Sars-Cov-2 infection could be a cause of acute pancreatitis. The mechanism by which this occurs remains to be established through in-depth studies on animal models or biopsy samples.