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Whipple’s disease is a rare infectious disease, the classic presentation of which is the combination of polyarthralgia, diarrhea, and weight loss. However, it can present in a wide variety of ways. Its incidence is 0.5 to 1 case per 1 million. If left undiagnosed and untreated, it can be fatal. Multifocal motor neuropathy with conduction block is a chronic pure motor neurological dysimmune disorder with an estimated prevalence of 1 to 2 cases per 100,000, which usually respond to treatment with intravenous immunoglobulins. We describe the case of a man in whom the diagnosis of these two pathologies was made concomitantly and whose favorable evolution under antibiotic therapy raises the question of a link between the two conditions.