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In a context of major societal challenges, the vulnerability of human societies to climate disruption and the collapse of biodiversity, we are witnessing an increase in health, environmental and safety crises, which can be summarized as major challenges. With the emphasis on prevention, we hypothesize that the inclusion of women is a lever for the effectiveness of collective action to prevent zoonoses in public policy and in the action strategies of civil society organizations. Hence, our interest in open social innovation. The research question being, how does the inclusion of women strengthen collective action and performance in the prevention of zoonoses. The aim is to understand the specific role played by women in collective action to prevent zoonoses, and then to conceptualize and theorize a system of collective action to prevent zoonoses. In order to support our argument in this paper, we will use an analytical framework on multi-level governance and a grid for analyzing public prevention policies.