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In our society, the arts and sciences have often been seen as separate: scientific or artistic studies, creative or research careers, distinct professional and partnership networks. For a long time, they developed in parallel without intersecting. In recent years, however, new connections have emerged, and programs combining arts and sciences are becoming more common (Fourmentraux, 2011). In this article, we focus on cultural projects that are innovative both in their structure and in the artistic and cultural experiences they offer. We explore how an environmentally responsible cultural initiative combining arts, sciences, and industry can be developed. What are the barriers and drivers to its implementation? How can it lead to social, environmental, or territorial innovation? Our analysis is based on a specific case study: an eco-responsible, mobile cultural institution initiated by the association Dans le sens de Barge. Keywords: Arts, Sciences, Culture, Innovation, Sustainable Development