During his 31-year tenure as director of the U.S. National Library of Medicine (NLM), Donald A.B. Lindberg M.D. dramatically increased access to knowledge about health issues, medicine, medical care, the health professions, and health literacy. As an enthusiastic visionary with a plan, his aim was to bring about a more efficient transfer and use of information and data. Dr. Lindberg and the NLM helped transform and reshape medicine and the health system in the 20th and 21st centuries. Dr. Lindberg envisioned, encouraged, and supported the development of electronic health records and telemedicine. Coupled with the evolution of the Internet, these technologies made health systems more efficient for research, the delivery of clinical services, the education of health professionals, bioethics, improving the public’s health literacy, and disease prevention strategies. Dr. Lindberg also was committed to enhancing the capacity of underserved and minority populations to make use of NLM’s health information resources. Transforming Biomedical Informatics and Health Information Access is a tribute to Don Lindberg and the NLM. The book is divided into four sections. The first documents the advances in biomedical informatics during Dr. Lindberg’s career, emphasizing the contributions made by teams of talented individuals at the NLM. The second section describes how the NLM’s creation of new methods of access to diverse biomedical databases improved information access for healthcare professionals, biomedical researchers, and the public. The third section explains how NLM’s outreach programs improved access to health information among underrepresented audiences and communities. The more informal fourth section provides brief memoirs about Dr. Lindberg’s life, character, and humanism.