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This article explores the distinction between “spiritual need” and “spiritual desire” within the biomedical context. It begins by defining these two concepts through medical references, particularly that of Virginia Henderson, who emphasizes the importance of spiritual needs in nursing care. The scientific debate surrounding these terms is examined, highlighting the divergent opinions of researchers and healthcare professionals. Some advocate for the use of the term “need,” while others prefer “desire,” which reflects a more subjective quest for spirituality. The article concludes that spirituality encompasses both need and desire, representing a continuous search for meaning and connection that is essential for patient well-being.