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Almost one-third of kidney donation candidates are incompatible (HLA and/or ABO) with their directed recipient. Paired kidney donation allows potential donors to be matched and produces compatible kidney transplants. The French Bioethics Law of 2011 allowed paired kidney donation with reciprocity between 2 incompatible “donor-recipient” pairs. A limited number of transplants have been performed due to excessive restrictions compared to other European practices. This study discusses future perspectives in light of the new French Bioethics Law, enacted in 2021, which broadens out the authorized practices for paired kidney donation in France. The two simulated future developments are the increase in the number of pairs involved in a paired kidney donation to 6 (compared to 2 currently), and the use of a deceased donor as a substitution for one of the living donors. Various scenarios are simulated using data from the French Biomedicine Agency: incompatible pairs registered in the paired kidney donation program in France between December 2013 and February 2018 (78 incompatible pairs), incompatible transplants performed during the same period (476 incompatible pairs), and the characteristics of deceased donors and offers made during this period. Increasing the number of pairs has a limited effect on the number of transplants, which increases from 18 (23% of recipients) in the current system to 25 (32% of recipients) when 6 pairs can be involved. The use of a deceased donor significantly increases the number of transplants to 41 (52% of recipients). This study evaluates the increase in possibilities for kidney transplants by paired kidney donation as a result of the new French Bioethics Law. A working group and an information campaign for health professionals and patients will be necessary to support its implementation.