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The MENA mergers and acquisitions (M&A) market is growing, but the lack of data and studies makes it incomprehensible. This paper aims to examine this market by analyzing the reaction of companies in the region during M&A and determining whether these operations create value for the shareholders of the acquirers. An event study was carried out using three models and a sample of 269 transactions in twelve countries over fifteen years. Our results indicate that Israel is the most active country, that 2008, 2010, and 2015 represent the years with the highest level of activity, and that the abnormal returns of the acquirers are generally positive and significant around the announcement date. Information leaks prior to this date are reported in some countries in this region.