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The theme of addictology constitutes here an entry point to analyze the constructions of partnerships, in particular between one French Intercommunal Social Action Center (CIAS) and a an addictology network. Based on the testimonies of professionals in the medical and social fields, this text shows how, in a context of medical desertification, collaborations were organized that were stable enough in time and space, but also flexible enough to take into account the needs of patient-users, and to readjust the relationships between “expert professionals” and “patient-users.”