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Given its prevalence among the general population and the major impact it has on patients’ quality of life, hemorrhoidal disease is a real topic of public interest. On a daily basis, doctors are faced with patients’ questions about the existence of potential triggering factors and, in particular, the role of spicy food in preventing and managing attacks. Despite the paucity of literature and the many complex physiopathology factors involved, this mini review takes stock of current knowledge on the potential link between hemorrhoidal disease and spices, in an attempt to unravel the myth from the reality of this commonly accepted relationship.