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Impact of the COVID-19 pandemic on national activity and risks associated with hematopoietic stem cell transplants

Par : Contributeur(s) : Type de matériel : TexteTexteLangue : français Détails de publication : 2023. Sujet(s) : Ressources en ligne : Abrégé : The global spread of SARS-CoV-2 in the spring of 2020 was responsible for significant morbidity and mortality, particularly in elderly, comorbid, or immunocompromised patients, such as hematopoietic stem cell (HSC) allograft recipients. COVID-19 also had a major organizational impact on the French healthcare system. This article first summarizes the impact of COVID-19 on HSC allograft activity (particularly from unrelated donors) in Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) centers in 2020. We then report on the characteristics of SARS-CoV-2 infections in patients receiving allogeneic HSC transplants, the risk factors for severity and mortality, and the humoral and cellular immune response of these patients to the SARS-CoV-2 vaccine.
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The global spread of SARS-CoV-2 in the spring of 2020 was responsible for significant morbidity and mortality, particularly in elderly, comorbid, or immunocompromised patients, such as hematopoietic stem cell (HSC) allograft recipients. COVID-19 also had a major organizational impact on the French healthcare system. This article first summarizes the impact of COVID-19 on HSC allograft activity (particularly from unrelated donors) in Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) centers in 2020. We then report on the characteristics of SARS-CoV-2 infections in patients receiving allogeneic HSC transplants, the risk factors for severity and mortality, and the humoral and cellular immune response of these patients to the SARS-CoV-2 vaccine.

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