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As part of the French public hospital accounting restatement, the new work unit (unité d’œuvre, UO) for pharmacy is more exhaustive and closer to the Société Française de Pharmacie Clinique frame of reference than its predecessor [5, 6]. This redefinition is expected to result in a better understanding of pharmacy organizations. The aim of this work was to examine how the UO’s reporting on organizational changes in our pharmacy Groupe Hospitalier Paul Guiraud (GHPG) can improve the quantitative and qualitative development of clinical pharmacy activities. Materials and method. This was an observational retrospective study carried out on a database. Data was recorded from the 2017 [3] and 2021 [4] annual activity reports of the GHPG pharmacy, from two internal studies on working time, from full-time hospitalization data during the study period [2], and from weighted time calculations using ANAP at 9 psychiatric hospital pharmacies. Data analysis was carried out using SPSS software (release 28.0.1). Results and discussion. The comparative study based on pharmaceutical dispensing weighted time (reference activity) and medication reconciliation weighted time (one activity of clinical pharmacy) between the GHPG pharmacy and the 9 psychiatric hospital pharmacies, shows that both are in the same range. Although our organizations, activities, resources, sizes, and budgets are different, the weighted time of these two main activities are close and reveals some homogeneity between the psychiatric hospital pharmacies in the corpus. During the study period, pharmaceutical dispensing increased by 10% when expressed in number of acts, decreased by 3% in weighted time, and their share within the UO reduced by 4.8%, from 42% to 40%. In this respect, the UO reports two opposite trends: an increase in the number of health products in the formulary and in the number of Covid-19-related customers, and a decrease in beds, linked to the crisis of public psychiatry. Clinical pharmacy activities increased by 2% when expressed in number of acts, increased by 26% in weighted activities, and their share within the UO increased by 26% from 5.8% to 7.3%. In this respect, the UO change reflects organizational changes in favor of the deployment of clinical pharmacy activities. Perspectives. The new UO illustrates the reorganization implemented over the last 5 years. But can it guide pharmacy managers and local decision-makers through decree n° 2019-489 05/21/2019 implementation related to hospital pharmacy? And will it shed light on the path to be taken within the framework of pharmaceutical cooperation associated with a pooling of technical and administrative functions, robotic dispensing, and deployment of clinical pharmacy activities in partner facilities that are not yet covered . . . ?