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IntroductionThe issue of the relevance and efficiency of medication prophylaxis for stress ulcers (SU) is frequently raised. Our objective was to analyze pharmaceutical intervention on medication prophylaxis for SU in the medical emergency unit of the University Hospital of Cocody, in Abidjan (Ivory Coast).MethodsThis was a cross-sectional study with a descriptive aim including patients admitted to the medical emergency unit of the University Hospital of Cocody from July 2021 to January 2022 and receiving medication related to SU prevention. Pharmaceutical analysis was conducted using the Calop algorithm. The decision tree developed by the French society of intensive care for the prevention of stress-related gastrointestinal bleeding in intensive care was used as a reference. The French Society of Clinical Pharmacy’s (SFPC) classification of Drug Therapy Problems (DTP) and Pharmaceutical Interventions (PI) was used. Prescribers’ ratings of potential clinical, economic, and organizational impacts of PIs were determined using the CLEO scale. The direct cost savings of accepted PIs were estimated.ResultsDTPs for the prevention of SU were performed in 87.5% of the 112 patients involved. “Non-compliance” (100%) and “discontinuation” (100%) were respectively the DTPs and PIs related to SU prevention. Seventy-one percent (71%) of PIs were accepted, all of which were rated as “PI with no clinical impact,” “PI reducing the cost of medication management,” and “PI with a positive organizational impact.” These PIs reduced the daily cost of medication management by an average of 23.8%.ConclusionPIs related to SU prevention are relevant and contribute to the therapeutic efficiency of patient care in the medical emergency unit in Abidjan.