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"Tranq," or "the zombie drug," is a drug that commonly combines xylazine and fentanyl. Addiction to this drug has become a scourge in the United States, where the number of overdoses related to the drug's consumption has increased exponentially since 2018. These two substances are the cause of mainly neurological effects, including motor inertia, dysarthria, and temporal and spatial disorientation; cutaneous effects with ulcers due to tissue hypoperfusion; and cardiovascular effects, including bradycardia and hypotension, and respiratory depression. Health care professionals treating these patients must focus on withdrawal management, but also be aware of the ineffectiveness of naloxone in counteracting side effects.