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Introduction: To correct bilateral Class II malocclusions or Class II subdivisions, various therapeutic options are available to the orthodontist, depending on the patient and the amount of tooth movement required. Retro-tuberosity screws (RTSs) represent one such alternative; however, they remain poorly documented in the literature. The aim of this article is to present a series of cases managed using RTSs. Materials and method: Four cases treated with RTSs are presented. Results: The patients include three women and one man, aged between 16 and 35 years. Three patients were treated with multi-bracket appliances and one with aligners. Discussion: RTSs enabled effective sequential distalization. Adverse effects were limited, except for the risk of vestibular-palatal angulation. Placement can be technically demanding and requires the absence of wisdom teeth. The failure rate seems comparable to that reported for the rest of the oral cavity if a 2 mm diameter screw is used. Conclusion: RTSs represent a relevant distalization option for the correction of Class II malocclusions or certain asymmetries in adults without third molars. To confirm their indications and limitations, randomized controlled trials need to be conducted.