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‪The origins of life and extraterrestrial life are at the basis of major scientific and societal questions, but also of major explorations. However, their media treatment remains an unexplored field in research on the mediatisation of science. This article studies the mediatisation of the origins of life in French and Francophone audiovisual media from 1959 to 2018. It is based on the statistical and semiotic analysis of two corpora of video productions corresponding to 120 television programmes and 134 videos broadcast on YouTube. The results show that this issue related to scientific news has been present in the media for almost 60 years. From a traditional media to a video hosting platform, its treatment continues (popularisation of science), but also shows mutations (dissemination of media forms, multiplication of actors/content producers; counter-narrative).‪