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Introduction: Cutaneous squamous cell carcinoma (SCC) is a common cancer resulting from the malignant proliferation of epidermal keratinocytes. It is the second most common type of skin cancer, with the potential for metastasis and recurrence. The most common locations of SCC are the face and torso, while its occurrence on the foot is rare. The aim of this study is to describe and analyze the epidemiological, clinical, therapeutic, and evolutionary aspects of patients being treated for SCC of the foot. Materials and methods: A retrospective multicentric study was conducted from January 2000 to December 2020 at the dermatology department of the Ibn-Rochd University Hospital in Casablanca and the National Center of Leprology of Casablanca. Results: In total, 20 patients were included in this study, consisting of 13 men and 7 women, with an average age of 58.74 years. A perforating plantar ulcer (PPU) was found in all 10 patients being treated for leprosy. The average time of progression before diagnosis was 18 years. The clinical appearance at diagnosis was dominated by an ulcerating lesion. Amputation was the main treatment in our patients. The progression was marked by the occurrence of metastases in 9 patients. Two patients died. Conclusion:The originality of this series of cases lies in the unusual location of SCC in the foot, since the main risk factor is the total dose of ultraviolet (UV) radiation accumulated over a lifetime. SCC may occur de novo or, more often, mark the progression of lesions considered to be non-invasive precursors. The malignant transformation of plantar ulcers in leprosy is not uncommon.