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To mark twenty years of the REIN (French Renal Epidemiology and Information Network), a summary report on the contributions of the French national end-stage kidney disease (ESKD) registry was produced. On ESKD prevalence, a number of key takeaways were identified. While chronic kidney disease affects all age groups, there are ever more patients requiring treatment in the older age groups, with a median age of 71.1 years (IQR 60.3-80.0) on dialysis and 58.7 years (IQR 47.4-68.3) with a kidney transplant. Despite an increase in transplant activity and improved graft survival, the gap between the number of dialysis patients and transplant patients at the end of each year has only moderately reduced. There has been a moderate decrease in the proportion of in-center hemodialysis, explained by a significant increase in medicalized dialysis units (out-center hemodialysis) and a decrease in self-care hemodialysis. Finally, rates of home-based care have remained stable despite ministerial incentives and the guidelines issued in the SFNDT white paper.© 2022 Société francophone de néphrologie, dialyse et transplantation. Published by Elsevier Masson SAS. All rights reserved.