Doctor Who is one of television’s most enduring and ubiquitously popular series. This study contends that the success of the show lies in its ability, over more than half a century, to develop its core concepts and perspectives: alienation, scientific rationalism and moral idealism. The most extraordinary aspect of this eccentric series rests in its capacity to regenerate its central character and, with him, the generic, dramatic and emotional parameters of the programme. Out of Time explores the ways in which the series’ immortal alien addresses the nature of human mortality in his ambiguous relationships with time and death. It asks how the status of this protagonist – that lonely god, uncanny trickster, cyber-sceptic and techno-nerd – might call into question the beguiling fantasies of immortality, apotheosis and utopia which his nemeses tend to pursue. Finally, it investigates how this paragon of transgenerational television reflects the ways in which contemporary culture addresses the traumas of change, loss and death.