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This exploratory study aims to investigate the impact of suspected markers, subsequently unconfirmed, during pregnancy on early mother–child bonding and postpartum depression symptoms. The Postpartum Bonding Instrument, Mother–Infant Bonding Scale, and Edinburgh Postnatal Depression Scale have been administered to 209 mothers, aged 20–40 years old, and having given birth in the last six months. Mothers who had suspected markers did not differ from the mothers of the control group in terms of global bonding scores, but some significant differences were found for items related to a danger in the mother–infant relationship. Moreover, they had higher postpartum depression symptom scores. The scores were even higher when a suspected marker was identified in the first trimester of pregnancy. These results highlight the need to pay more attention to the potential impact of these markers on a psychological level. Coming back to the experience of these markers after delivery could help to reduce their impact on the prevalence of depression symptoms.