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The aging of people with disabilities and the evolution of their conditions imply an increased need for support and care. In institutions for people with disabilities, social educators and nurses are increasingly called upon to work together within socio-educational teams. Based on the perspective of the sociology of professional groups and works on interprofessional collaboration, this article analyzes the interprofessional collaboration between social educators and nurses in institutions for people with disabilities in French-speaking Switzerland, based on the perspectives of the professionals concerned and employers. Interviews provide insight on the processes of redefining the areas of intervention between social educators and nurses, by pointing out two institutional modalities of division of labor in the consulted structures, formal distinction and no formal distinction, the issues they raise, and how professionals make them their own. The results also highlight the good collaboration between these professions, the areas of tension, and the elements that influence interdisciplinary collaboration.