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The prison population is less healthy than the general population and has more frequent co-morbidities, including addictions. The 2003 Drees survey showed that 33% of new prisoners declared a prolonged and regular use of illicit drugs in the 12 months prior to incarceration. We wanted to describe the use of psychoactive substances and the associated risk practices in prison. We conducted nine semi-directed qualitative interviews among drug users who have experienced incarceration in Brest prison. We have highlighted the continued use of licit (tobacco, medical treatments) and illicit (heroin, cocaine, cannabis) drugs in prison with risk-associated practices (sniffing, injection...). The ubiquitous solicitations and drug trafficking with well-known strategies such as barter and exchange were also found in the goal. The respondents also suggested several possible areas for improvement in the care of drug users in prison, based on the diversification of care, including better access to risk reduction, and patient autonomy.