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The aim of this paper is to contribute to the discussion on the anticipated long-term impact of the post-crisis regulatory environment on bank stability and efficiency, with a focus on Central and Eastern European (CEE) banks. The main research question is whether relatively stable CEE banks, operating in an unstable global environment, will be negatively affected by post-crisis European regulatory architecture. To answer this question, this paper analyses how CEE banks performed in two different periods: the pre-crisis period of dynamic credit market expansion and the period of global economic slowdown after 2008 crisis. Bank efficiency and performance is measured using DEA methodology, competitive conditions’ measures (H-statistics) and Z-score index.