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American psychoanalysts have integrated some references to neurobiology and immunology in their clinical work, presenting them as models of psychobiological regulation-deregulation in the exchanges between the central nervous system and the immune system. Somatic illnesses are seen as disorders of biological regulations. These models, derived from systems theory, provide us with the opportunity of renewing the relationship between psychoanalysis and somatic illness. An example is given which refers to the notion of the self and its fragmentation. The evolution of a treatment is followed with its technical adjustments of a counter-transferential and interpretative nature.