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Memory processes, notably episodic memory, are classically subtended by the hippocampus and more broadly by the medial temporal lobe. However, a larger cerebral network underpins memory processes and, in this context, the contribution of the frontal lobes has frequently been highlighted. Their roles have been specified by studies using functional brain imaging in healthy subjects and in different memory diseases. This brief review presents the main conclusions of recent studies, with a particular focus on older subjects, as well as amnesic patients of different etiologies.