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In this article, we try to give an account of the way Diderot treats the productive character of the mind, relating aspects of his epistemology and his aesthetics with three theoretical instances. Firstly, this question touches the problem of invention as a rhetorical method which becomes assimilated by Bacon and Descartes to a method leading to discovery. Secondly, Diderot, who emphasizes the use of hypothesis, defines knowledge as a kind of anticipation, as it is defined in the modern epicureanism. Finally, regarding aesthetics, Diderot puts forth a theory of the « modèle idéal » which is tied to a nominalist conception of the abstraction. These three aspects of Diderot's thought are important, in our opinion, for the formation of a materialist theory of knowledge.