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A seven-year-long research conducted among siblings of children with cancer has yielded a central hypothesis according to which these siblings suffer from the psychic consequences of the realization of an unconscious death wish against the sick child. The description of key moments of the therapy of a little boy whose twin sister died of cancer show how much, beyond any generalizations, the specificity of the clinical encounter between a therapist and a willing subject allows for the emergence of certain elements that clarify the central hypothesis. The doubt as to the need for therapy, the role of the various family members, and their defense mechanisms when confronted with such a painful situation, as well as the place left for the healthy sibling within the family group emerge as crucial questions. Lastly, the description and in-depth work of the therapy leads to the confirmation that the healthy sibling is doomed to know.