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In their discussion, Isabelle Garo and Anne Sauvagnargues reexamine the intellectual and political evolution of Deleuze and Guattari, focusing on their relation to Marx and to the Marxism of their time. In particular, they confront their interpretations of the way the works jointly authored by Deleuze and Guattari can be placed within the May 1968 moment and its aftermath. They also reflect on the implications of Deleuze and Guattari’s relation to Freudo-Marxism. The underlying question is that of the political meaning of their work and the possibility of a renewal of Marxism which might take them as its starting point.