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Often it is precisely within the framework of security and preventive measures that fear flares up and is exacerbated, a fear that takes on new forms and throws into sharp relief the complexity of the human condition and the necessity of taking ethical responsibilities into account. The author examines the present-day forms of this fear by looking at their subjective resonances, but also their relationship to the current state of predictive medicine and the sociopolitical context. Experience shows us that, in many cases, it is paradoxically upon learning of his illness or genetic destiny that the subject becomes a stranger to himself and to his own body. In all predictive methods there is a residue of unpredictability, of what cannot be determined. In dealing with this limit, the encounter between medicine and psychoanalysis can prove to be especially productive.