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In this article, I examine the issue of segregation, both on a psychological level and in terms of social relationships, and the term developed by Jacques Lacan: desegregation. This work leads us to consider the symbolic resources of segregation and its decisive effects on the question of brotherhood and racism. Different topological models are proposed, drawing upon the works of Peter Sloterdijk and Giorgio Agamben, in order to figure out the connections between segregation and desegregation and to foresee their consequences on the human and subjective experience.