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This article discusses research themes that introduce new perspectives on communication at a time of flux in the contours that define humanity. Interfaced humanity is humanity that questions its singularity, as the frontiers of what is human become blurred with those of technology, nature and the animal. Three themes are discussed here: points of abutment of communication that become its fulcrum; written sign language where the living and the symbolic intersect; humans as new watchmakers of their own bodies faced with the impossible homeostasis of body and mind. There is an urgent need in the information and communication sciences to address the question of human communication at a time of convergence, through the notion of data, between the living and the artificial, in order to open up theoretical debates on these themes. Many authors of reflections on humanity in recent years have opened up new ways of thinking on human communication. The question now is to discuss how far the emergence of interfaced humanity and its relationships with what is artificial are changing human communication and thinking.