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Palliative care teams are regularly faced with the issue of artificial nutrition for terminally ill patients. We set up a prospective monocentric descriptive study to evaluate the conformity of parenteral nutrition prescriptions in the palliative care unit of the Oscar Lambret Center with the recommendations of the FNCLCC (Fédération Nationale des Centres de Lutte contre le Cancer). For nine months, nineteen patients were included among 135 hospitalizations. For each one we collected clinical data and parenteral nutrition parameters, and we conducted a clinical and nutritional follow-up at fifteen days, one month, and two months. Seventeen patients died less than three months after beginning parenteral nutrition, and follow-up could not be completed due to the rapidly declining health condition of most of the patients. Prescriptions of parenteral nutrition were not in accordance with the Standards, Options, and Recommendations. It is however a complex decision, which cannot be limited to strict recommendations and must be part of a global and individualized approach to patient care. This study allowed us to advise the hospital care unit on some improvements to the management of palliative care patients.