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Observation: We report the case of Mr. T, of Bosnian origin, in a situation of extreme social precarity, who presented with Sharp’s syndrome, discovered two years prior. He was hospitalized repeatedly and over long periods for surgical complications related to his disease. He presented with “problems of adjustment” in the surgery department. We met following nine months of hospitalization, when the patient complained of acute diarrhea with severe aftereffects preventing his release home, and which the surgeons could not explain. The surgeons then asked for the liaison psychiatrist’s opinion regarding a possible psychiatric disorder. Discussion: The questions posed by the surgeons and the patient’s previous history suggested a diagnosis of a painful somatic symptom disorder. The patient had been treated in parallel for depression over the previous five months. Cognitive impairment in this patient could have been linked to the sequelae of an ischemic stroke or a central nervous system disorder. Specific Aspects: This patient had a severe cognitive impairment and was in a socially precarious situation. Furthermore, Sharp’s syndrome is a systemic disease that can present significant psychiatric manifestations, as in Lupus. The underlying pathophysiological mechanisms related to these psychiatric disorders are poorly known, and involve inflammatory, immunological, and infectious mechanisms. In addition, this patient had significant psychiatric and somatic comorbidities. Working together, social worker and nephrologist were able to achieve appropriate overall care management of this patient. Conclusion: Mr. T, suffering from Sharp’s syndrome, presented with a painful somatic symptom disorder. The liaison psychiatrist recommended a multidisciplinary transversal management of the patient.