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Artificial Intelligence (AI) is applied to many activities, including healthcare. Based on two studies, this article aims to investigate the role of AI in healthcare sustainability by analyzing AI acceptance from the perspective of the United Theory of Acceptance and Use of Technology (UTAUT) and through the lens of the United Nations Sustainable Development Goals (SDGs), organized around three pillars: economy, environment and society. Our research uses a mixed method approach: a quantitative survey of medical staff and qualitative interviews with experts (AI and health). The findings confirm the importance of technology-trusting performance for AI solution acceptance, the impact of performance expectancy, habit and personal innovativeness on usage intention and the influence of technology anxiety. The qualitative study confirms that the societal, economic and ecological improvement-oriented SDGs are important in maintaining healthcare sustainability. Our results also shed light on the challenges faced when environmental goals lack a practical focus. JEL Codes: I12, J28, J81, M15, M54, O33